maxxipaws maxxiSAMe Advanced SAM-e Powder Supplement - Liver, Cognitive & Joint Support for Dogs, 5.3oz

Update 10/15/2025: Hi there, me again. Now that it is 8 years later, Barney's adopted little brother Maximus is well into his senior years. He's in great shape for his age, which we estimate to be around 13 years (he's a rescue pittie), but he's started showing some signs of cognitive decline - restlessness, pacing, and panting, especially at night. We are managing his relatively mild arthritis stiffness with meds from our vet, thinking that's why he was so agitated, but the cognitive symptoms persisted. That's when I remembered how much this supplement helped our Barney all those years ago. We've been loyal to the Maxxi brand this whole time - Max gets the Omega oil and MaxxiDigest on his food daily to help with his coat and tummy (ya boy gets some serious diarrhea and gas that'll knock you out without it) - so I can't believe it took me this long to remember that MaxxiSAMe exists. Unlike Barney, Max gobbles this stuff right up with his food, no weird cheese sushi roll required. Thank you, MaxxiPaws, for continuing to put out a quality product. ---- Final Barney update 5/24/2017: This will be my final update to this review, as we unfortunately had to say goodbye to our wonderful dog Barney last week after his slow onset of degenerative myleopathy had progressed too far. I cannot say enough good things about the MaxxiDog company as they helped us find solutions to make Barney's last year+ as comfortable and happy as it could be. I truly believe that the MaxxiSAMe product had a positive effect for Barney and was key in making his last time with us a happy one, as it really seemed to help mitigate his symptoms of Canine Cognitive Dysfunction (CCD). I have changed my review to five stars to reflect this. Please continue reading below for the original review, and the other updates on how we ended up using the product. (Spoiler: The most effective way to get Barney to eat it was to do two small pumps of MaxxiOmega oil with it to make a paste, and then put the paste in American cheese like a weird little sushi roll! He never turned his nose up at this option.) Thank you again to the MaxxiDog company for your excellent product and wonderful customer service. ---- (Original review:) My dog Barney is well into his golden years and has is showing some pretty strong signs of canine cognitive dysfunction (CCD; basically, doggie dementia) such as night waking/panting, getting lost or stuck in corners, licking, digging at the floor, and fecal incontinence. So, I powered up the ol' computer and did some research. It turns out there isn't a ton you can do for it once they've got it, but there are supplements that can help manage some of the symptoms and keep it from progressing as quickly. Enter: SAMe and choline. These two seemed to pop up the most in my searches but my head was spinning about what product to buy. Well, this MaxxiSAMe stuff handily has both! Awesome! Now, a little bit about Barney - Barney has been anywhere from 77 to 90 pounds since I've known him. This dog LOVES to eat. He's not picky, either - he eats 'yard treats' (if you catch my drift) regularly, for goodness sake. He once ate a raw zucchini off the floor (and immediately threw it up, but that's beside the point). Now that we've been more careful about his portion sizes he acts like we're starving him to death (I assure you, we are not) and scavenges even more. But as soon as I put this stuff on his food, Barney went on a hunger strike. He will NOT touch the stuff. It's crazy. I even tried burying cheese in his bowl thinking he'd at least eat his way down to the cheese - NOPE. Not interested. I really wish this came in pill form. I've resorted to trying to squish the dosage up in cheese and give it to him that way, which is pretty difficult since he is on the highest dosage (1 tsp per dosage, twice a day), and the supplement needs to be inside the cheese for him to eat it. I have made some messes. I think my next attempt may involve deli meat since that won't fall apart like cheese slices... though now I have visions of Barney biting into the powder ball in the meat and causing an explosion. He's only had his full dosage(ish... the part that hasn't scattered out of the cheese all over the floor anyway) for a day or two. If I notice some improvement or come up with a better method of administration, I'll absolutely come back and edit my review. I really, really want to love this product. But for now, I give it 5 stars in theory and Barney gives it a 1 star in taste so we'll compromise and call it a 3. ---- UPDATE 4/28/2016: We went through two jars of this stuff, and multiple administration methods (since adding it straight to dry food was NOT an option). First I'll talk about the effects it has had on him, and then I will talk about how we've been giving it to him. EFFECTS: After giving him two jars of this, I didn't buy a third. After a few days of not being on it, his CCD symptoms increased fairly dramatically - walking around panting/whining at night, getting lost in corners, pooing inside, etc. He was still doing some of those things SOMETIMES, so it's possible that the timing of his symptoms was coincidental with stopping the MaxxiSAMe. However, I had forgotten just how bad his symptoms used to be, especially the night symptoms - we were all sleeping very terribly for a few days there. So I bought another jar hoping it would help him, and I think it has. We all slept through the night better the last couple of nights, anyway! This is why I've upped my rating to 4 stars (was previously 3). ADMINISTRATION: Oh boy. Well, the folks at MaxxiSAMe were kind enough to respond to my review in both email form and comment form (below) and include some ideas for getting him to take it, which is super awesome of them. Here is what we've tried, and what has and hasn't worked - 1. Paste method: Add a small amount of water to make a thick paste. Give to dog like treat. This worked for maybe a couple of weeks, and now he just turns his nose away from it when I try to give it to him this way. The MaxxiSAMe folks also suggested mixing it with something he likes, but I don't think this would work, for reasons I'll get to in a moment. 2. Soft food method: Barney was on meds that made his stomach upset for a while, so to get him to eat, I would add warm water to his dry kibble food to make it soft and appealing. I could add the MaxxiSAMe directly to the soft food and he'd eat it right up. *shrug* 3. Paste + cheese method: This is what we're doing now. I add a VERY small amount of water to make a thick paste, which I form into a ball with my fingers. Then I smash cheese around it so that none (or at least very little) of the MaxxiSAMe ball is showing. If it is showing, he will not touch the stuff - or sometimes will sort of "work" at it to get the cheese off and spit the MaxxiSAMe out. This is why I don't think it would work to mix the paste with something he enjoys: he would still know the MaxxiSAMe is in there. I think this method would work better with lunch meat, but that's not something we normally have around the house, and it goes bad faster than cheese slices. This method would probably work okay with a PillPocket type treat that has a large enough pocket. So, in conclusion, Barney still thinks the stuff is super gross which makes administration a bit of an ordeal, but I have reason to believe it might be helping his CCD so that outweighs any difficulties in giving it to him. I do still wish it came in tablet form; I picture it being like Cosequin, where it's not a coated tablet but more of a compressed powder type tablet that can be broken if needed. Thanks again to the makers of this product for supplying such a high quality product, and for responding to reviews in such a thoughtful, detailed way! ---- UPDATE 6/17/2016: After my last update, the owners of MaxxiSAMe were not content that Barney still wasn't super into the stuff. They actually sent me a free bottle of their MaxxiOmega oil to try mixing that with the MaxxiSAMe, which is super awesome of them. Turns out, it totally worked. I mix his SAMe dosage with about a pump and a half of the oil, smear it on a piece of cheese and wrap the cheese sushi-style, and he gobbles it right up. He still won't QUITE eat it without cheese (though he acts like he MIGHT when I've offered it to him), but I at least don't have to try to smash the cheese all around it to hide every speck of the MaxxiSAMe. Thank you!!

I have a 15 year old Chihuahua diagnosed with liver issues when I took him in to be neutered 14 years ago (still almost a puppy). So, he has lived with very high liver enzymes most of his life....and when I say high, extremely high to the point that most vets question if the blood panel came back correctly. Long story short, he's lived a long and good life with no symptoms up until 2 to 3 years ago. That's when I started him on this product, maxxiSAMe. I sprinkled a little on his food in the morning and at night. I never really knew what it was doing except that symptoms were NOT worsening. Well, that jar lasted over a year, but when I ran out and he was off of this for a few weeks, the strange behavior returned and became more noticeable. He was circling, disoriented, lethargic and more aggressive. I got him right back on the maxxiSAMe again when the new jar arrived. Without a doubt, the symptoms of the liver issues eased up. Now, I don't want to give false hope. I have NOT found this to be a miracle drug, and it will not cure liver damage from all I've read and researched, but I strongly believe IT HELPS PREVENT more damage to the liver and keeps dogs with liver issues stabilized to some extent. I know this to be true on my dog anyway. To end, even in the past 3 months I started switching the maxxiSAMe at nights for some hemp oil to help with my dog's arthritis, and although the hemp oil helped, the lack of the maxxiSAMe at nights was noticeable. My dog started head pressing worse than I ever saw him at nights. He got very disoriented until I got him back on this product again TWICE a day rather than just one dose in the mornings. The trick for me has been to give a little on his food in the morning and a little in the evening. My baby is old and in the very late or end stages of the liver disease, no doubt, but as long as he's eating well, comfortable and not in extreme pain, I can't and I won't put him down. He's not ready to leave this world yet, but I can strongly verify that this product has made a difference and has given him more time on earth and more quality of life than if he was not on it.

I am a new customer to MaxxiDog, specifically the new, high-quality MaxxiSAMe product. It really caught my eye because my 13-year-old lab has high liver numbers. Tests indicated she does not have Cushings Disease. Still, her veterinarian - who practices Western and Eastern disciplines - had me put her on a coated pill form of the SAMe. Of course, I complied but I found the schedule and administration of the pills troublesome in that they needed to be given an hour before meals, and on an empty stomach. Timing had to be just right, which can be a challenge in a busy household. However, MaxxiDog is formulated to be given ​WITH food, and with no benefits loss. This is of real value to dogs and their parents because its ease of administration nearly guarantees no missed doses. I simply added the powder to her food and NO problem! My dog licked her bowl clean! Of special note on this important supplement: it contains additional ingredients to support the liver that you will not find in most SAMe supplements. You will easily find all of the ingredients on the product page. I will be keeping my beloved dog on this product. Additionally, I also give my lab Milk Thistle as per the veterinarian. I sincerely want to thank MaxxiDog for offering such a complete and high-quality a product that addresses a chronic health issue affecting so many pets, but mostly for providing an easy way to deliver the supplement! Thank you so much from a happy - and soon to be repeat- customer!

Update: Seller reached out and was kind enough to explain the product and reimburse the cost. I really appreciate that and it tells me they stand behind their products and truly care about the wellbeing of the pets their products are used on. I will look into Maxxipaws other products and maybe introduce this one back into Buddy's regimen since he tolerated it well with no side effects. Unfortunately this product did not work for my dog. He has elevated liver ALK which was at 1,800 when I first introduced him to this product along with a milk thistle supplement. It's been almost a few months and recently had his blood work rechecked again and it has gone up to over 2,000! Very disappointing as this is a very expensive product! Everything has been ruled out with my dog, had a cushions test done and an ultrasound done on his liver which both tests came back with no issues. I'm really upset because I had this on subscription which already had gone through the day of his blood work. So now I'm stuck with a brand new unopened jar that I paid over $60.00 that doesn't accept refunds. PS. SAMe is supposed to be given on an empty stomach, I'm thinking that could possibly be the reason this product does not work.

I previously gave our 10-yr old pointer a chewable SAMe tablet to help control unexplained elevated liver values, but manufacturer changed the formula and our dog would no longer eat it unless buried in food. Since it needed to be given on an empty stomach, that was not ideal. I regularly search for any alternative products--finding nothing much different--and suddenly there was MaxxiSAMe claiming to be fine given with food. Information on the product said it was beneficial for liver health as well as cognitive function. I wasn't looking for the latter, but didn't think it would be in any way a harmful effect. After a brief period of slowly introducing this powder--she didn't care for the flavor, due I assume to the heavy artichoke taste--she began happily eating her food with this supplement in it. It was helpful that she gets some wet food; when it was just dry food the powder would fall to the bottom more readily and got left there. After several weeks we were surprised to notice that she was reverting to more energetic, alert, puppy-like behaviors, and since nothing else had changed we attribute this to improved cognitive function from MaxxiSAMe. I have recommended MaxxiSAMe to my veterinarian who agreed it looks great and seems worthy of trial by other patients. I gave it only 4 stars because the taste was a hurdle for our dog to get over. Also--although I have no reason to blame this product--her liver values have increased a bit, which is not uncommon for her from time to time anyway; but I give her SAMe to manage them so time will tell how they might fluctuate as she stays on this product. As long as they don't spiral out of control, the SAMe is helping, and the cognitive benefit is huge. UPDATE 11/26/17 -- Recently my pointer had her liver values checked again and they were much lower than before! That was the only hold-up in giving this product five stars, so now I can do that and confirm that this product has been great. I have come to trust this company and also have started my dog on their MaxxiFlex joint supplement to help with her arthritis and this is helping her too.

We have a 15-year-old rescue dachshund who is having issues with elevated liver enzymes. Our vet gave us denamarin which has to be administered on an empty stomach. There was NO WAY we could get Mollie to take it. Finally I started cutting it up and putting with a little canned salmon. It was a small amount of food but at least we were getting it in her. Then she got wise to it and and nothing we tried from that point on worked. Her enzymes were continuing to go up without any SAMe and I was getting desperate to find an alternative. I bought this product because it said it could be administered with food. Our dog is soooo finicky and I honestly didn't think she would eat food with this mixed in. But to our surprise, she actually likes it. She was a little hesitant at first but grew used to it really quickly. We've been using this product for about 2 months. We just saw the vet this week for bloodwork and her enzymes have come down a little. Our vet was impressed because without any product, her enzymes would have been up significantly. So even though it wasn't a huge lowering of her numbers, it was promising that they actually went down and didn't elevate. I'm anxious to see how her numbers are affected after we've been using this product for another several months. It is a little expensive, but to me, if it helps our old girl have a longer, more comfortable life, it's worth every penny.

My dog, Ginny, has liver cancer. She can still live longer as long as we keep a very close eye on her blood values and diet. I could not afford the expensive Denamarin. I put her on this along with a cheap Milk Thistle supplement and give both twice daily. Within 3 days her coat became more luxurious. It was shiny and silky where before it was dull and dry. I'm going to do a little TMI but her poop went from bright orange to normal and it also helped the GI upset that she had been having, also due to her liver cancer. I mean, I want to stop short of saying that this thing is a "miracle drug" simply because I am a human nurse and there is no such thing. Still, I never would have imagined how well this worked out for her. If I had to say something I don't like it would be the flavor, which needs enhancing. The flavor was not something she cared for. I started mixing it with some yogurt and a very little applesauce. She really likes it with that and the yogurt and applesauce also help the GI upset. My veterinarian was skeptical. She insisted that I buy Denamarin but as I said, I cannot afford it. However, when she saw her liver values after only a month and a half, she was sold. She wants me to bring the container when I finish with it so she can recommend it to others to see if that helps them. This is much cheaper than anything else that I can find on the market, if you find something else, please comment and let me know. I did miss a couple of doses due to emergency circumstances (I broke my hand and had to have surgery) and I will say that within two days she was back to orange poops and her fur changed back to dry and dull. About that same time I figured out how to handle it with my giant cast with pins and such. All in all, I really stand by this stuff. I would say it is probably pretty healthy for dogs without illness but check with your own vet first, of course. You can never be too sure.

There are two problems I have with this product: 1) It did nothing for my cat's liver enzyme levels after 6 months of recommended dosage on an empty stomach. The numbers got worse, despite additional application of Pet Wellbeing - Milk Thistle for Cats - Natural Support for Feline Liver health - 2oz (59ml) that whole time. 2) According to all my research, SAM-e must be given on an empty stomach for both humans and pets, otherwise it is much less effective. How do you give a cat some loose powder on an empty stomach? That's right, you put it in capsules. So I had to get capsules and spend quite a bit of time filling them. Then I had to convince the cat to take them, so I had to buy Pill Pockets also. Now it's not quite an empty stomach, and a lot of work. I'm switching to Denamarin, despite the costs, and I'll retest in a few months.

Our eldest dachshund had a very high liver enzyme count when bloods were taken, following major gastric surgery. Our vet recommended a tablet that contained various ingredients to support the liver. The tablet brought his enzymes down, but, it is very expensive for a months supply, and on some days I would find the soggy tablet later in the day hidden near the fridge freezer. Reading reviews online, I became aware of several customers who had similar issues , and had tried the Maxxi SAMe instead with great results. Had a good read up, the SAMe quantity was identical, with silybjn too, from a different source, but also several other excellent ingredients , such as vitamin B12, B6, B1, B2 inositol, and choline. These are very important for nervous system and brain function. Plus the fact , that the tub is very generous for the money. So you get more benefit for a far more resonable cost . My dog has 1/4 scoop twice a day ,which is 1.25 gms for his weight of 6.6 kg. I purchased this tub in March and will need my next tub in July . The final clincher for this product, is the advice and customer service from the manufacturer. They have a great website with a dedicated phone line. When I phoned to discuss withholding Maxxi Cardio for a few days before his dental surgery, they were extremely knowledgeable and helpful. It's unusual, in my experience, to find people so invested in getting products that benefit pets. This is possibly because they all are pet owners and use these products themselves. I also had a very nice follow up email regarding dosage of Maxxi Joint for my younger dachshund. Milo had routine bloods taken before his dental in May, since he is almost 15 and surgery not without risk . Our vet stated that for his age, the bloods were good, and liver enzymes are now only mildly elevated, which is as expected for his age and pancreatic issues. Our vet was even more impressed with his recovery at his 10 day post op check , as were we. He is a different dog and I am convinced that introducing Maxxi Cardio (which I have also reviewed) was crucial to his well being as he had become quite weak with a heart murmur. If you are tempted to try the Maxxi Paws products, then contact with the customer service will no doubt help your decision, and give you good guidance. For us , Maxxi Same and Maxxi Cardio play a big part in our dachshund's fantastic health, and have hugely improve his quality of life .

A mi perro le vá fantástico. Tiene problemas con el higado y lo necessita para vivir bien.

Questo è una buonissima schelta per il tuo cane!

Acheter pour aider mon Bouledogue Français qui a fait un avc. On verra avec le temps, l’efficacité du produit…

Ganz tolles Mittel. Hat die Leberwerte meines Schatzes innerhalb von drei Wochen von über 1.100 auf 350 senken können🙏🏻.... Die Werte sind zwar immer noch zu hoch, ich hoffe jedoch, dass wir bei der nächsten Kontrolle dann im Normalbereich liegen. Ich habe das Pulver allerdings nicht über das Essen gegeben, sondern mit Wasser vermischt zu einer Paste direkt ins Mäulchen☺️