Pharmacological Evaluation Of Acalypha Indica Linn: Hepatoprotective and Branchodilation activity of Leaves of Acalypha indica Linn

Descripción

Uncontrolled environmental pollution, poor sanitary conditions, alcohol intoxication and indiscriminate use of potent drugs predispose liver to a vast array of disorders. Asthma is one of the most common disorders encountered in clinical medicine in both children and adults characterized by inflammation of the airway that is central to airway dysfunction. Effect of ethanol and aqoues extract of the leaves of Acalypha indica (Euphorbiaceae) was investigated against carbon tetra chloride-induced hepatic damage and Bronchodilator activity . carbon tetra chloride at the rate of 1 ml/kg produced liver damage in rats as manifested by the significant (P>0.001) rise in serum levels of AST,ALT,ALP compared to respective control values. Treatment of animals with the plant extract (200 and 400 mg/kg) orally once daily for 7 days prevented (P>0.01) the carbon tetra chloride -induced rise in serum transaminases (AST and ALT) and ALP. Bronchodilator activity studied on the spasmolytic activity on guinea pig isolated tracheal chain and Milk induced Eosinophillia and leukocytosis in mice. These results suggest that aqueous extract of the Acalypha indica Linn. has prove bronchodilating activity